The Paper Feed

A feed of Bayesian network related papers, articles, books and research that we happen across and find of interest

Partial Least Squares Discriminant Analysis and Bayesian Networks for Metabolomic Prediction of Childhood Asthma

Kelly, R.S. and McGeachie, M.J. and Lee-Sarwar, K.A. and Kachroo, P. and Chu, S.H. and Virkud, Y.V. and Huang, M. and Litonjua, A.A. and Weiss, S.T. and Lasky-Su, J.
To explore novel methods for the analysis of metabolomics data, we compared the ability of Partial Least Squares Discriminant Analysis (PLS-DA) and Bayesian networks (BN) to build predictive plasma metabolite models of age three asthma status in 411 three year olds (n = 59 cases and 352 controls) from the Vitamin D Antenatal Asthma Reduction Trial (VDAART) study. The standard PLS-DA approach had impressive accuracy for the prediction of age three asthma with an Area Under the Curve Convex Hull (AUCCH) of 81%. However, a permutation test indicated the possibility of overfitting. In contrast, a predictive Bayesian network including 42 metabolites had a significantly higher AUCCH of 92.1% (p for difference < 0.001), with no evidence that this accuracy was due to overfitting. Both models provided biologically informative insights into asthma; in particular, a role for dysregulated arginine metabolism and several exogenous metabolites that deserve further investigation as potential causative agents. As the BN model outperformed the PLS-DA model in both accuracy and decreased risk of overfitting, it may therefore represent a viable alternative to typical analytical approaches for the investigation of metabolomics data.
Posted 30 Oct 2018 · Open Link · Link

Modeling interrelationships between health behaviors in overweight breast cancer survivors: Applying Bayesian networks

Xu, Selene AND Thompson, Wesley AND Kerr, Jacqueline AND Godbole, Suneeta AND Sears, Dorothy D. AND Patterson, Ruth AND Natarajan, Loki
Obesity and its impact on health is a multifaceted phenomenon encompassing many factors, including demographics, environment, lifestyle, and psychosocial functioning. A systems science approach, investigating these many influences, is needed to capture the complexity and multidimensionality of obesity prevention to improve health. Leveraging baseline data from a unique clinical cohort comprising 333 postmenopausal overweight or obese breast cancer survivors participating in a weight-loss trial, we applied Bayesian networks, a machine learning approach, to infer interrelationships between lifestyle factors (e.g., sleep, physical activity), body mass index (BMI), and health outcomes (biomarkers and self-reported quality of life metrics). We used bootstrap resampling to assess network stability and accuracy, and Bayesian information criteria (BIC) to compare networks. Our results identified important behavioral subnetworks. BMI was the primary pathway linking behavioral factors to glucose regulation and inflammatory markers; the BMI-biomarker link was reproduced in 100% of resampled networks. Sleep quality was a hub impacting mental quality of life and physical health with > 95% resampling reproducibility. Omission of the BMI or sleep links significantly degraded the fit of the networks. Our findings suggest potential mechanistic pathways and useful intervention targets for future trials. Using our models, we can make quantitative predictions about health impacts that would result from targeted, weight loss and/or sleep improvement interventions. Importantly, this work highlights the utility of Bayesian networks in health behaviors research.
Posted 25 Oct 2018 · Link

Reducing COPD Readmissions: A Causal Bayesian Network Model - IEEE Journals

S. Lee and S. Wang and P. Bain and C. Baker and T. Kundinger and C. Sommers and J. Li
This paper introduces a causal Bayesian network model to study readmissions reduction for chronic obstructive pulmonary disease (COPD) patients. The model employs a Bayesian network learning method and adopts domain knowledge. Using this model, we analyze the impacts of critical variables on a patient's readmission risk by manipulation of such variables. Through this analysis, effective intervention options to reduce readmission can be identified, which can provide a quantitative tool for designing personalized interventions to reduce COPD readmissions.
Posted 21 Oct 2018 · Link